DeSoto County Drug Rehabs & Treatment

Oxford Outpatient Treatment Center is located at 1150 Church Road West in Southaven, Mississippi, under the Oxford Treatment Center brand of American Addiction Centers. According to SAMHSA's 2026 survey, it provides outpatient and intensive outpatient substance use treatment for adults, with private insurance and self-pay accepted.

Region IV MHS in Hernando, Mississippi is an office of Region IV Mental Health Services, a community mental health center serving north Mississippi. According to SAMHSA's 2026 survey, it provides outpatient and intensive outpatient substance use treatment, medication-assisted treatment, and DUI programs, with telehealth available. The center accepts Medicaid, Medicare, and CHIP and offers sliding-fee discounts.